abstract：:During prolonged anoxia at low temperature, freshwater turtles develop high plasma concentrations of both lactate and calcium. At these concentrations the formation of the complex, calcium lactate, normally of little biological significance because of the low association constant for the reaction, significantly reduce...

journal_title：Respiratory physiology & neurobiology

authors： Jackson DC

更新日期：2004-12-15 00:00:00

abstract：:Central histaminergic neurons are distributed in areas of the medulla and pons concerned with respiratory rhythm generation, but their effects on breathing pattern are unknown. We examined breathing pattern during hypercapnic responses in wild type (WT) and H1 receptor knockout (H1RKO) mice at 9-10 weeks of age before...

journal_title：Respiratory physiology & neurobiology

authors： Miyamoto K,Iwase M,Kimura H,Homma I

更新日期：2004-11-30 00:00:00

abstract：:Neurons of the pontine respiratory group (PRG) in the region of the nucleus parabrachialis medialis and the Kolliker-Fuse nucleus are believed to play an important role in promoting the inspiratory (I) off-switch (IOS). In decerebrate gallamine-paralyzed cats ventilated with a cycle-triggered pump system (lung inflati...

journal_title：Respiratory physiology & neurobiology

authors： Cohen MI,Shaw CF

更新日期：2004-11-15 00:00:00

abstract：:Respiratory rhythm generators appear both evolutionarily and developmentally as paired segmental rhythm generators in the reticular formation, associated with the motor nuclei of cranial nerves V, VII, IX, X, and XII. Those associated with the Vth and VIIth motor nuclei are "pontine" in origin and in fishes that emplo...

journal_title：Respiratory physiology & neurobiology

authors： Milsom WK,Chatburn J,Zimmer MB

更新日期：2004-11-15 00:00:00

abstract：:Respiratory responses to single intermittent hypoxia (5 min 21% O(2), 5 min 8% O(2) X6) in 5-6, 10-11, 21-22 and 26-27 day-old piglets, and to recurrent six daily intermittent hypoxia in 10-11 and 26-27 day-old piglets were assessed. Substance P binding in the piglets' brainstem immediately after the last hypoxic epis...

journal_title：Respiratory physiology & neurobiology

authors： Laferrière A,Moss IR

更新日期：2004-10-12 00:00:00

abstract：:The purpose of this study was to simultaneously examine left-ventricular (LV) function and pulmonary gas exchange during prolonged constant-rate cycling in an attempt to explain the exercise-induced impairment in gas exchange. Eleven competitive cyclists rode their racing bicycles on a computerized cycle trainer at 25...

journal_title：Respiratory physiology & neurobiology

authors： Stickland MK,Anderson WD,Haykowsky MJ,Welsh RC,Petersen SR,Jones RL

更新日期：2004-09-15 00:00:00

abstract：:A murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) was used to evaluate whether aquaporin-1 (AQP1) is involved in lung inflammation and lung edema formation. Swiss strain mice (n = 122) had LPS (5 mg/kg) instilled intratracheally (IT), and were then treated with either 0.9 % saline or dexametha...

journal_title：Respiratory physiology & neurobiology

authors： Su X,Song Y,Jiang J,Bai C

更新日期：2004-08-20 00:00:00

abstract：:While the brains of most vertebrates are unable to tolerate more than a few minutes of anoxia, some freshwater turtles (Trachemys and Chrysemys), crucian carp (Carassius carassius) and frogs (Rana pipens and Rana temporaria) can survive anoxia for hours to months. Obviously, anoxia tolerance has evolved separately sev...

journal_title：Respiratory physiology & neurobiology

authors： Lutz PL,Nilsson GE

更新日期：2004-08-12 00:00:00

abstract：:GABA and adenosine contribute to respiratory inhibition in early postnatal life. In this study the adenosine A2A receptor agonist CGS21680 was used to evaluate adenosine receptor specificity and the interrelation of adenosine and GABA in the inhibition of inspiratory drive. In neonatal piglets (n = 10), CGS21680 was i...

journal_title：Respiratory physiology & neurobiology

authors： Wilson CG,Martin RJ,Jaber M,Abu-Shaweesh J,Jafri A,Haxhiu MA,Zaidi S

更新日期：2004-07-20 00:00:00

abstract：:Recently, we have shown that the expired CO2 gas volume versus tidal volume (VCO2-VT) curve is a useful tool for assessing unevenness of ventilation because it allows the separation of tidal volume into three functional compartments: (a) the CO2-free expired air (V0), (b) the transitional volume (Vtr), (c) the alveola...

journal_title：Respiratory physiology & neurobiology

authors： Koulouris NG,Latsi P,Stavrou E,Chroneou A,Gaga M,Jordanoglou J

更新日期：2004-06-25 00:00:00

abstract：:Maximal metabolic rate (MMR) of mammals scales differently from basal metabolic rate (BMR). This is first shown by scrutinizing data reported on exercise-induced Vo2 max in 34 eutherian mammalian species covering a body mass range of 7 g-500 kg. Vo2 max was found to scale with the 0.872 (+/-0.029, 95% confidence limit...

journal_title：Respiratory physiology & neurobiology

authors： Weibel ER,Bacigalupe LD,Schmitt B,Hoppeler H

更新日期：2004-05-20 00:00:00

abstract：:Our aim was to determine whether maternal cigarette smoking affects arousal and ventilatory responses to hypoxia in infants. Infants born to non-smoking (NS, n = 15) and smoking mothers (SM, n= 9) were studied at 2-5 weeks, 2-3 and 5-6 months. Ventilatory responses to 15% O(2) were determined preceding arousal. At eac...

journal_title：Respiratory physiology & neurobiology

authors： Parslow PM,Cranage SM,Adamson TM,Harding R,Horne RS

更新日期：2004-04-20 00:00:00

abstract：:Acetylcholine (ACh) acting through muscarinic receptors is thought to be involved in the control of breathing, notably in central and peripheral chemosensory afferents and in regulations related to sleep-wake states. By using whole-body plethysmography, we compared baseline breathing at rest and ventilatory responses ...

journal_title：Respiratory physiology & neurobiology

authors： Boudinot E,Yamada M,Wess J,Champagnat J,Foutz AS

更新日期：2004-02-25 00:00:00

abstract：:Pulmonary mechanics [static (Est) and dynamic (Edyn) elastances, resistive (DeltaP1) and viscoelastic pressures (DeltaP2)], histology, and bronchoalveolar lavage fluid (BALF) from BALB/c mice were analysed 1, 24, 48 and 72 h after intravenous injection of saline or Bothrops jararaca crude venom [0.3 (V0.3) or 1 (V1) m...

journal_title：Respiratory physiology & neurobiology

authors： Silveira KS,Boechem NT,do Nascimento SM,Murakami YL,Barboza AP,Melo PA,Castro P,de Moraes VL,Rocco PR,Zin WA

更新日期：2004-01-15 00:00:00

abstract：BACKGROUND:Our recently developed murine asthma model is capable of inducing airway-specific chronic inflammatory changes and remodeling, features of human asthma commonly missing in conventional animal models. OBJECTIVES:To validate this model by site-specific physiological evaluation of hyperresponsiveness. METHODS...

journal_title：Respiratory physiology & neurobiology

authors： Collins RA,Sly PD,Turner DJ,Herbert C,Kumar RK

更新日期：2003-12-16 00:00:00

abstract：:This study examined the effects of five nights of normobaric hypoxia on ventilatory responses to acute isocapnic hypoxia (AHVR) and hyperoxic hypercapnia (AHCVR). Twelve male subjects (26.6 +/- 4.1 years, standard deviation (S.D.)) slept 8-9 h per day overnight for 5 consecutive days at a simulated altitude of 4,300 m...

journal_title：Respiratory physiology & neurobiology

authors： Ainslie PN,Kolb JC,Ide K,Poulin MJ

更新日期：2003-11-14 00:00:00

abstract：:The adult elephant is unique among mammals in that the pleural membranes are thickened and the pleural cavity is obliterated by connective tissue. It has been suggested that this peculiar anatomy developed because the animal can snorkel at depth, and this behavior subjects the microvessels in the parietal pleura to a ...

journal_title：Respiratory physiology & neurobiology

authors： West JB,Fu Z,Gaeth AP,Short RV

更新日期：2003-11-14 00:00:00

abstract：:In animals, high-intensity unilateral stimulation of the phrenic nerve results in short-latency inhibition of phrenic and intercostal nerve activity bilaterally. This study provides the first demonstration in human subjects of a short-latency inhibitory response in the contralateral scalene, parasternal intercostal an...

journal_title：Respiratory physiology & neurobiology

authors： Butler JE,McKenzie DK,Gandevia SC

更新日期：2003-10-16 00:00:00

abstract：:Classical understanding of airway lumen narrowing in asthma has held that the isometric force generated by airway smooth muscle (ASM) must be at every instant in a static mechanical equilibrium with the external load against which the muscle has shortened. It has been established recently, however, that this balance o...

journal_title：Respiratory physiology & neurobiology

authors： Fabry B,Fredberg JJ

更新日期：2003-09-16 00:00:00

abstract：:Airway smooth muscle maintains airway tone and may assist in adjusting ventilation distribution within the normal lung. Alterations in the properties or the quantity of ASM are likely responsible for some instances of airways hyperresponsiveness to bronchoconstrictive stimuli that is a characteristic of diseases such ...

journal_title：Respiratory physiology & neurobiology

authors： Martin JG,Ramos-Barbón D

更新日期：2003-09-16 00:00:00

abstract：:Theoretical data for the alveolar amplitude response technique (AART) (J. Appl. Physiol. 41 (1976) 419-424) for assessing lung function was simulated using a single path lung model. This model takes account of stratified inhomogeneities in gas concentrations within the respiratory tree. The data was inserted into prev...

journal_title：Respiratory physiology & neurobiology

authors： Whiteley JP,Gavaghan DJ,Hahn CE

更新日期：2003-08-14 00:00:00

abstract：:Tibetans are the oldest population living permanently at high altitude. They possess several adaptations to low oxygen pressure that improve oxygen transport. We hypothesised that native Tibetans have mechanisms allowing them to maintain a better sleep structure and oxygenation during sleep at high altitude than newco...

journal_title：Respiratory physiology & neurobiology

authors： Pływaczewski R,Wu TY,Wang XQ,Cheng HW,Sliwiński PS,Zieliński J

更新日期：2003-07-16 00:00:00

abstract：:We develop tidal-ventilation pulmonary gas-exchange equations that allow pulmonary shunt to have different values during expiration and inspiration, in accordance with lung collapse and recruitment during lung dysfunction (Am. J. Respir. Crit. Care Med. 158 (1998) 1636). Their solutions are tested against published an...

journal_title：Respiratory physiology & neurobiology

authors： Whiteley JP,Farmery AD,Gavaghan DJ,Hahn CE

更新日期：2003-06-12 00:00:00

abstract：:Functional genomics is a systematic and high-throughput effort to analyze the functions of genes and gene products. Functional genomics is divided into gene- and phenotype-driven approaches. Gene-driven approaches to the functional genomics of sleep have demonstrated that transcripts of many genes change as a function...

journal_title：Respiratory physiology & neurobiology

authors： Mackiewicz M,Pack AI

更新日期：2003-05-30 00:00:00

abstract：:Chronically hypoxic humans and some mammals have attenuated ventilatory responses, which have been associated with high dopamine level in carotid bodies. Alveolar hypoventilation and blunted ventilatory response have been recognized to be at the basis of Chronic Mountain Sickness by generating arterial hypoxemia and p...

journal_title：Respiratory physiology & neurobiology

authors： Gamboa J,Macarlupú JL,Rivera-Chira M,Monge-C C,León-Velarde F

更新日期：2003-04-15 00:00:00

abstract：:The dependence of metabolic rate (MR) on body mass (M) is described by the general allometric equation MR=aM(b), where, a is a proportionality coefficient and b is the mass exponent. Darveau et al. [Nature 417 (2002), 166] proposed a novel 'multiple-causes' allometric cascade model as a unifying principle of the scali...

journal_title：Respiratory physiology & neurobiology

authors： Batterham AM,Jackson AS

更新日期：2003-04-15 00:00:00

abstract：:Swallowing is a powerful inhibitor of respiratory rhythm in infants. The present study was aimed at investigating the influence of states of alertness on non-nutritive swallowing (NNS) frequency, on NNS and respiration coordination, and on bursts of NNS frequency in newborn lambs. Six full term newborn lambs were inst...

journal_title：Respiratory physiology & neurobiology

authors： Reix P,Fortier PH,Niyonsenga T,Arsenault J,Létourneau P,Praud JP

更新日期：2003-03-28 00:00:00

abstract：:We previously showed that medroxyprogesterone acetate (MPA) effectively decreases the arterial CO(2) levels in postmenopausal women with partial upper airway obstruction. The aim of the present study was to analyze the effects of MPA on the inspiratory flow shapes during sleep. Eight postmenopausal women with hypoxemi...

journal_title：Respiratory physiology & neurobiology

authors： Saaresranta T,Aittokallio T,Polo-Kantola P,Helenius H,Polo O

更新日期：2003-03-03 00:00:00

abstract：:The postnatally developing lungs of the quokka wallaby, Setonix brachyurus, were investigated macroscopically and by light microscopic morphometry. Lung, parenchymal and non-parenchymal volumes as well as the components of the latter two were analysed by regression analysis. The lungs comprised a single undivided left...

journal_title：Respiratory physiology & neurobiology

authors： Makanya AN,Haenni B,Burri PH

更新日期：2003-02-19 00:00:00

abstract：:Technical limitations have precluded measurement of the V(O(2)) profile within contracting muscle (mV(O(2))) and hence it is not known to what extent V(O(2)) dynamics measured across limbs in humans or muscles in the dog are influenced by transit delays between the muscle microvasculature and venous effluent. Measurem...

journal_title：Respiratory physiology & neurobiology

authors： Behnke BJ,Barstow TJ,Kindig CA,McDonough P,Musch TI,Poole DC

更新日期：2002-11-19 00:00:00

abstract：:Our aim was to observe the induction of panic attacks (PA) symptoms by a breath-hold test in panic disorder (PD) patients as the Diagnostic and Statistical Manual for Mental Disorders 4th edition (DSM-IV) and their healthy first-degree relatives. We randomly selected 26 PD patients, 28 healthy first-degree relatives o...

journal_title：Respiratory physiology & neurobiology

authors： Nardi AE,Nascimento I,Valença AM,Lopes FL,Zin WA,Mezzasalma MA,Versiani M

更新日期：2002-10-23 00:00:00

abstract：:Loss of alveolar barrier function is important in the development of pulmonary edema, but quantitation of its integrity has been difficult in the intact lung. We report a new non-radioactive method to assess paracellular and transcellular permeability of alveolar barrier in buffer-perfused rabbit lungs. Changes in alv...

journal_title：Respiratory physiology & neurobiology

authors： Huang YC,Piantadosi CA

更新日期：2002-10-23 00:00:00

abstract：:This project aimed to investigate the direction of artificial sputum movement during mechanical ventilation (MV) and bagging (MH) using a tube model. Three solutions of artificial sputum (ultrasonic gel, viscosity 100, 200 and 300 poise (P)) were prepared. About 1 ml of gel was placed in a glass tube connected to a te...

journal_title：Respiratory physiology & neurobiology

authors： Jones AY

更新日期：2002-09-04 00:00:00

abstract：:Within the moderate exercise intensity domain, the speed of oxygen uptake (V(O(2))) kinetics at the transition to a higher metabolic rate is thought to be limited by an inertia of the oxidative machinery. Nitric oxide (NO)-induced inhibition of O(2) consumption within the electron transport chain may contribute to thi...

journal_title：Respiratory physiology & neurobiology

authors： Kindig CA,McDonough P,Erickson HH,Poole DC

更新日期：2002-08-30 00:00:00

abstract：:In response to the increase in oxygen tension at birth, the resistance pulmonary arteries dilate, while the ductus arteriosus constricts. Although modulated by the endothelium, these opposite responses are intrinsic to the vascular smooth muscle. While still controversial, it seems likely that during normoxia the prod...

journal_title：Respiratory physiology & neurobiology

authors： Weir EK,Hong Z,Porter VA,Reeve HL

更新日期：2002-08-22 00:00:00

abstract：:Respiratory effects of intracarotid injection of gamma-amino-butyric acid (GABA) were investigated in two groups of rats. In the first group of 12 rats the effects of GABA were checked in the intact state, following bilateral vagotomy and GABA receptor blockade. The second group consisted of five initially vagotomized...

journal_title：Respiratory physiology & neurobiology

authors： Kaczyńska K,Szereda-Przestaszewska M

更新日期：2002-08-01 00:00:00

abstract：:A possible mechanism underlying adaptive control of the respiratory system is gain modulation of the discharge frequency (F(n)) patterns of medullary respiratory neurons mediated by GABA(A) receptors. Antagonism of GABA(A) receptors with bicuculline results in an F(n) pattern that is an amplified replica of the underl...

journal_title：Respiratory physiology & neurobiology

authors： Zuperku EJ,McCrimmon DR

更新日期：2002-07-01 00:00:00

abstract：:Recurrent sleep apnea (RSA), mimicking chronic intermittent hypoxia (CIH), may trigger unique adaptations in oxygen sensing in the carotid body, and consequent cellular functions unlike the effects of sustained hypoxia (SH). As a mechanism, an augmented generation of reactive oxygen species (ROS) in CIH has been invok...

journal_title：Respiratory physiology & neurobiology

authors： Lahiri S,Di Giulio C,Roy A

更新日期：2002-06-01 00:00:00

abstract：:A computational fluid dynamics (CFD) modelling approach is used to study the unsteady respiratory airflow dynamics within a human lung. The three-dimensional asymmetric bifurcation model of the central airway based on the morphological data given by Horsfield et al. (J. Appl. Physiol. 67 (1971) 207) was used in the pr...

journal_title：Respiratory physiology & neurobiology

authors： Calay RK,Kurujareon J,Holdø AE

更新日期：2002-04-01 00:00:00

abstract：:A simple mathematical model of the carotid body chemoreceptor response is presented. The model assumes that the static chemoreceptor characteristic depends on oxygen saturation in the arterial blood and on CO2 arterial concentration. The values of O2 saturation and of CO2 concentration are computed, from pressure, usi...

journal_title：Respiratory physiology & neurobiology

authors： Ursino M,Magosso E

更新日期：2002-03-01 00:00:00